CRYSTAL STRUCTURE OF THE TERNARY MTX NADPH COMPLEX OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE OXIDOREDUCTASE, PSEUDO-ROSSMANN FOLD, ADENINE NUCLEOTIDE BINDING DOMAIN, ANTIBIOTIC RESISTANCE, METHOTREXATE RESISTANCE, NADP, ONE-CARBON METABOLISM, TRIMETHOPRIM RESISTANCE 3DAU