MGEKVYIFDTTLRDGEQAPGFSMTTEEKLQMAHQLAKLNVDIIEAGFAAASKGDFEAVNRIAKEVKGPVICSLARALESDIEIAAKALEPAERKRIHTFIATSPIHMEYKLRMTPDQVLERIKKAVSFARNFTDDVEFSCEDATRSEREFLYRAIETAIKHGATVINIPDTVGYAIPEEFGQLIEDIMNNVPNIDKVILSVHCHDDLGLATANSLTAVKHGARQVECTINGIGERAGNAALEEVVMALKVRKDFFGDLYTDVNTKEIYKTSRLLCRITGNFVQPNKAIVGDNAFAHESGIHQHGVLSHRMTYEIMNPEDVGFPMSRIVLGKHSGRHALKRRLEELGFKFTKEELDRIFEKFKELADRKKEVYDEDLEALIYQEFMKIEDHEPVKVLHFQVQSGDNMIPTATVKLEFKGEEREASSTGNGPVDATIKAIQKALGIEPKLLDYSIKALTPNTDAQAEARVVLELDGVKASGRGVDTDIIKASVKAFTDALNRAIVRKEYIIQRQEIREEGTV Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity). 2-isopropylmalate synthase aq_2090 LEU1_AQUAE 520 Alpha-IPM synthase Alpha-isopropylmalate synthase leuA