The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is an helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity). RUVB_BIFLD ruvB MSETTDYGASNTGANEESLRMVSSQPIGNEPVSDEELRPHVLGGFIGQPRLKAQLQLFLDAARKRDVPPDHILLAGPPGLGKTTLAMIVANELEVPIRVTSGPAVQHAGDLASILSSLDVGEVLFIDEIHRLPRAAEELLYIAMEDFRVDVMVGKGPGASSIPLTLPRFTVIGATTREGMLPSPLRARFGFTAHLDFYPHEELEKLIERSANVLGVNLDTGSAHELALRSRGTPRIANRLLRRVRDWAIVHDLIVVRPDDVKEALALYQIDSEGLDRLDIAVLNAIVRNFNGGPVGLNNLAAMVGEESETVETVCEPYLVREGFMIRTPKGRVATELADIIFGNYAQR Holliday junction ATP-dependent DNA helicase RuvB 348 BLD_0453