<rdf:RDF
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    xmlns:ns5="http://creativecommons.org/ns#"
    xmlns:ns8="http://metadb.riken.jp/db/SciNetS_ria349i/"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#"
    xmlns:ns1="http://metadb.riken.jp/db/SciNetS_ria214i/"
    xmlns:ns3="http://database.riken.jp/sw/item/">
  <ns1:cria214s7i rdf:about="http://metadb.riken.jp/db/SciNetS_ria214i/cria214s7ria214u2400004044i">
    <ns1:pria214s7i rdf:resource="http://metadb.riken.jp/db/SciNetS_ria214i/cria214s7ria214u2690626095i"/>
    <ns1:pria214s7i rdf:resource="http://metadb.riken.jp/db/SciNetS_ria214i/cria214s7ria214u2693013084i"/>
    <ns1:pria214s9i xml:lang="en">Serine/threonine-protein kinase Sak</ns1:pria214s9i>
    <ns8:pria349s10i rdf:resource="http://metadb.riken.jp/db/SciNetS_rib166i/crib166u26rib166u9606i"/>
    <ns1:pria214s7i rdf:resource="http://metadb.riken.jp/db/SciNetS_ria214i/cria214s7ria214u2693013142i"/>
    <ns1:pria214s7i rdf:resource="http://metadb.riken.jp/db/SciNetS_ria214i/cria214s7ria214u2681834150i"/>
    <ns1:pria214s9i xml:lang="en">Polo-like kinase 4</ns1:pria214s9i>
    <rdfs:seeAlso rdf:resource="http://database.riken.jp/sw/item/cria214s7ria214u2400004044i"/>
    <ns1:pria214s3i xml:lang="en">Serine/threonine-protein kinase that plays a central role in centriole duplication. Able to trigger procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins such as SASS6, CENPJ/CPAP, CP110, CEP135 and gamma-tubulin. When overexpressed, it is able to induce centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole during S phase. Its central role in centriole replication suggests a posible role in tumorigenesis, centrosome aberrations being frequently observed in tumors. Also involved in trophoblast differentiation by phosphorylating HAND1, leading to disrupt the interaction between HAND1 and MDFIC and activate HAND1. Phosphorylates CDC25C and CHEK2/CHK2.</ns1:pria214s3i>
    <ns1:pria214u1i xml:lang="en">STK18</ns1:pria214u1i>
    <ns1:pria214u1i xml:lang="en">SAK</ns1:pria214u1i>
    <ns1:pria214s6i xml:lang="en">Serine/threonine-protein kinase PLK4</ns1:pria214s6i>
    <ns1:pria214s7i rdf:resource="http://metadb.riken.jp/db/SciNetS_ria214i/cria214s7ria214u1173508037i"/>
    <ns4:hasFile rdf:resource="http://metadb.riken.jp/dbfiles/SciNetS_ria214i/cria214s7i/cria214s7ria214u2400004044i/O00444.fasta"/>
    <ns1:pria214s9i xml:lang="en">Serine/threonine-protein kinase 18</ns1:pria214s9i>
    <ns1:pria214s7i rdf:resource="http://metadb.riken.jp/db/SciNetS_ria214i/cria214s7ria214u1122710210i"/>
    <ns1:pria214s7i rdf:resource="http://metadb.riken.jp/db/SciNetS_ria214i/cria214s7ria214u1173508167i"/>
    <ns5:attributionURL rdf:resource="http://www.uniprot.org/uniprot/O00444"/>
    <ns1:pria214s2i xml:lang="en">PLK4</ns1:pria214s2i>
    <ns1:pria214s8i xml:lang="en">MATCIGEKIEDFKVGNLLGKGSFAGVYRAESIHTGLEVAIKMIDKKAMYKAGMVQRVQNEVKIHCQLKHPSILELYNYFEDSNYVYLVLEMCHNGEMNRYLKNRVKPFSENEARHFMHQIITGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLATQLKMPHEKHYTLCGTPNYISPEIATRSAHGLESDVWSLGCMFYTLLIGRPPFDTDTVKNTLNKVVLADYEMPSFLSIEAKDLIHQLLRRNPADRLSLSSVLDHPFMSRNSSTKSKDLGTVEDSIDSGHATISTAITASSSTSISGSLFDKRRLLIGQPLPNKMTVFPKNKSSTDFSSSGDGNSFYTQWGNQETSNSGRGRVIQDAEERPHSRYLRRAYSSDRSGTSNSQSQAKTYTMERCHSAEMLSVSKRSGGGENEERYSPTDNNANIFNFFKEKTSSSSGSFERPDNNQALSNHLCPGKTPFPFADPTPQTETVQQWFGNLQINAHLRKTTEYDSISPNRDFQGHPDLQKDTSKNAWTDTKVKKNSDASDNAHSVKQQNTMKYMTALHSKPEIIQQECVFGSDPLSEQSKTRGMEPPWGYQNRTLRSITSPLVAHRLKPIRQKTKKAVVSILDSEEVCVELVKEYASQEYVKEVLQISSDGNTITIYYPNGGRGFPLADRPPSPTDNISRYSFDNLPEKYWRKYQYASRFVQLVRSKSPKITYFTRYAKCILMENSPGADFEVWFYDGVKIHKTEDFIQVIEKTGKSYTLKSESEVNSLKEEIKMYMDHANEGHRICLALESIISEEERKTRSAPFFPIIIGRKPGSTSSPKALSPPPSVDSNYPTRERASFNRMVMHSAASPTQAPILNPSMVTNEGLGLTTTASGTDISSNSLKDCLPKSAQLLKSVFVKNVGWATQLTSGAVWVQFNDGSQLVVQAGVSSISYTSPNGQTTRYGENEKLPDYIKQKLQCLSSILLMFSNPTPNFH</ns1:pria214s8i>
    <ns1:pria214s4i>970</ns1:pria214s4i>
    <rdfs:label xml:lang="en">PLK4_HUMAN</rdfs:label>
  </ns1:cria214s7i>
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