TR11B_BOVIN 402 Osteoprotegerin TNFRSF11B MNKLLCCALVFLDISIKWTTQETFPPKYLHYDPESSRQLMCDKCPPGTFLKQPCTARRKTVCAPCPDHYYTDTWHTSDECLYCSPVCKELQYVKQECSRTHNRVCECEEGRYLELEFCLKHRSCPPGFGVLHPGTPERNTVCKRCPDGFFSNETSSKAPCRKHTNCSAFGLLLTQKGNATHDNICSGSSESSTHKCGIDMTLCEEAFFRFAVPTKLTPNWLSVLVDNLPGTKVNAESIERIKQRHNSREQTFQLLKLWKHQNKDQDMVKKIIQDIDLCENSVRRHIGHLNLTFEQLLKLMESLPGKKVTTEDVEKTVKTCKSSEQLLKLLSLWRIKNGDQDTRKGLLHALKHLKTYHFPKTVIQSLKKTIRFLHSFTMYRLYRKLFLEMIGNQVQSLKISCL Tumor necrosis factor receptor superfamily member 11B Acts as decoy receptor for RANKL and thereby neutralizes its function in osteoclastogenesis. Inhibits the activation of osteoclasts and promotes osteoclast apoptosis. Bone homeostasis seems to depend on the local RANKL/OPG ratio. May also play a role in preventing arterial calcification. May act as decoy receptor for TRAIL and protect against apoptosis. TRAIL binding blocks the inhibition of osteoclastogenesis (By similarity).