Thyroid receptor-interacting protein 13 PCH2 MDEAVGDLKQALPCVAEAPTVHVEVHQRSCSTAKKEDIKLSVRKLLNRHNIVFGDYKWNEFDDPFLARNVQSVSIVDTELKVKDPQPIDLGACTIALHVFQLNEGGPSSETLEEETENITAASHWVLPAAEFHGLWDSLVYDVEVKSHLLDYVMTTLLFSDKNVDSNLIAWNRVVLLHGPPGTGKTSLCKALAQKLTIRLSSRYQYGQLIEINSHSLFSKWFSESGKLVTKMFQKIQDLIDDKDALVFVLIDEVESLTAARNACRAGTEPSDAIRVVNAVLTQIDQIKRHCNVVILTTSNITERIDVAFVDRADIRQYIGPPSAAAIFKIYLSCLEELMKCQIIYPRQQLLTLRELEMIGFIENNVSKLSLLLSEISRKSEGLSGRVLRKLPFLAHALYIQAPTVTIEGFLQALSLAVDKQFEERKKLSSCI Thyroid hormone receptor interactor 13 Pachytene checkpoint protein 2 homolog Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double- strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By similarity). PCH2_CANFA TRIP13 432