ARID5B AT-rich interactive domain-containing protein 5B MEPNSLQWVGSPCGLHGPYIFYKAFQFHLEGKPRILSLGDFFFVRCTPKDPICIAELQLLWEERTSRQLLSSSKLYFLPEDTPQGRNSDHGEDEVIAVSEKVIVKLEDLVKWVHSDFSKWRCGLQAGAVKTTALGRNGQKEALLKYRQSTLNSGLNFKDVLKEKADLGEDEEETNVIVLSYPQYCRYRSMLKRIQDKPPSILTDQFALALGGIAVVSKNPQILYCRDTFDHPTLIENESICDEFAPNLKGRPRKKKPCPQRRDSFSGVKDSNNNSDGKAVAKVKCEARSALSKPKNNHNNCKKVSNEEKPKVAIGEECRADEQAFLVALYKYMKERKTPIERIPYLGFKQINLWTMFQAAQKLGGYETITARRQWKHIYDELGGNPGSTSAATCTRRHYERLILPYERFIKGEEDKPLPPIKPRKQENSSQENENKTKVSGTKRIKHEIPKSKKEKENAPKPQESPEVSSEPEKEQETSNQKSITEPLPAAEGKRKMEGYQDFAARPVGSRADPEKDSDADRGAGGATAAEEAGEQGPVPPLPSAPAAPDRGPALGPGAGKQPLTSPSAPADSKQEPQPCCFAESPDSEPQEPPFPGFPAAQPPLASQSELEEDKLPAMADYIANCTVKVDQLGSDDIHNALKQTPKVLVVQSFDMFKDKDLTGPMNENHGLNYTPLLYSRGNPGIMSPLAKKKLLSQVSGAGLSGSYPYGSPPPLISKKKLIPRDELCSGLPQAHPGQGSDHAAVSRPSVIQHVQSFRSKASEERKGLGDLFKHDKLGRSEPHRCSFSKHHLGPLADSYALKPDAPEGKDKLLEKRALPHAHVPSFLADFYSSPHLHSLYRHAEHHLHAEQTSKYACRDAYRESENSSFPAHKHQEKLHVNYLASLHLQDKKPAPAEAPADEQPTDLSLPKNLHKPTGKVLGLAHAAPGPQESKGAPQFPAGNGQSRDGHPKACRVSPMTLSAPKKYPEPLSRASRPHHVRLESFRKLEGMVHPVLHRKAGPQAVGAARPIKRGLEDLDLVIAGKKARAVSPLDPPKEACGKDKGAELEGEGGKAAAAHGGPAADGHKAALSSPIFPGLYSGSLCGSGLGSRLPAGYSHSLQYLKNQTVLSPLMQPLAFHSLVMQRGIFTSPTNSQQLYRHLAAATPVGSSYGDLLHNSIYPLAAINPQAAFPASQLSSVHPSTKL ARI5B_CANFA Transcription coactivator that binds to the 5'-AATA[CT]- 3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-337, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2- ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation (By similarity). 1187