HSD11K DHI2_SHEEP 427 NAD-dependent 11-beta-hydroxysteroid dehydrogenase HSD11B2 MESWPWPSGGAWLLVAARALLQLLRADLRLGRPLLAALALLAALDWLCQRLLPPLAALAVLAATGWIVLSRLARPQRLPVATRAVLITGCDSGFGNATAKKLDAMGFTVLATVLDLNSPGALELRACCSSRLQLLQMDLTKPADISRVLEFTKVHTASTGLWGLVNNAGQNIFVADAELCPVATFRTCMEVNFFGALEMTKGLLPLLRRSSGRIVTVSSPAGDMPFPCLAAYGTSKAALALLMGNFSCELLPWGVKVSIILPACFKTESVKDVHQWEERKQQLLATLPQELLQAYGEDYIEHLNGQFLHSLSQALPDLSPVVDAITDALLAAQPRRRYYPGHGLGLIYFIHYYLPEGCGRVSCSPSSSVPMCQEHYRLPAWPYLCPGHSPGPRPQTGPLSHCPVSRAHVEQLQQRRFLVPLLFFQVF Corticosteroid 11-beta-dehydrogenase isozyme 2 11-beta-hydroxysteroid dehydrogenase type 2 Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.