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  <ns1:cria224u4i rdf:about="http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u18007598i">
    <ns5:pria35u5i xml:lang="en">26</ns5:pria35u5i>
    <ns5:pria35u3i xml:lang="en">Sanchez-Moran Eugenio</ns5:pria35u3i>
    <ns5:pria35u6i xml:lang="en">24</ns5:pria35u6i>
    <ns5:pria35u3i xml:lang="en">Uanschou Clemens</ns5:pria35u3i>
    <rdfs:seeAlso rdf:resource="http://database.riken.jp/sw/item/cria224u4ria224u18007598i"/>
    <rdfs:label xml:lang="en">Uanschou Clemens et al. 2007 Dec. EMBO J. 26(24):5061-70.</rdfs:label>
    <ns5:pria35u3i xml:lang="en">Novatchkova Maria</ns5:pria35u3i>
    <ns5:pria35u3i xml:lang="en">Woglar Alexander</ns5:pria35u3i>
    <ns5:pria35u3i xml:lang="en">Schlögelhofer Peter</ns5:pria35u3i>
    <ns5:pria35u3i xml:lang="en">Siwiec Tanja</ns5:pria35u3i>
    <ns5:pria35u2i rdf:resource="http://metadb.riken.jp/db/SciNetS_ria43i/cria43u1ria43u3588i"/>
    <ns5:pria35u9i xml:lang="en">2007 Dec</ns5:pria35u9i>
    <ns5:pria35u3i xml:lang="en">Akimcheva Svetlana</ns5:pria35u3i>
    <ns4:attributionURL rdf:resource="http://www.ncbi.nlm.nih.gov/pubmed/18007598"/>
    <ns5:pria35u13i xml:lang="en">A novel plant gene essential for meiosis is related to the human CtIP and the yeast COM1/SAE2 gene.</ns5:pria35u13i>
    <ns5:pria35u3i xml:lang="en">Kerzendorfer Claudia</ns5:pria35u3i>
    <ns5:pria35u7i xml:lang="en">5061-70</ns5:pria35u7i>
    <ns5:pria35u3i xml:lang="en">Klein Franz</ns5:pria35u3i>
    <ns5:pria35u8i xml:lang="en">18007598</ns5:pria35u8i>
    <ns5:pria35s10i xml:lang="en">Obligatory homologous recombination (HR) is required for chiasma formation and chromosome segregation in meiosis I. Meiotic HR is initiated by DNA double-strand breaks (DSBs), generated by Spo11, a homologue of the archaebacterial topoisomerase subunit Top6A. In Saccharomyces cerevisiae, Rad50, Mre11 and Com1/Sae2 are essential to process an intermediate of the cleavage reaction consisting of Spo11 covalently linked to the 5' termini of DNA. While Rad50 and Mre11 also confer genome stability to vegetative cells and are well conserved in evolution, Com1/Sae2 was believed to be fungal-specific. Here, we identify COM1/SAE2 homologues in all eukaryotic kingdoms. Arabidopsis thaliana Com1/Sae2 mutants are sterile, accumulate AtSPO11-1 during meiotic prophase and fail to form AtRAd51 foci despite the presence of unrepaired DSBs. Furthermore, DNA fragmentation in AtCom1 is suppressed by eliminating AtSPO11-1. In addition, AtCOM1 is specifically required for mitomycin C resistance. Interestingly, we identified CtIP, an essential protein interacting with the DNA repair machinery, as the mammalian homologue of Com1/Sae2, with important implications for the molecular role of CtIP.</ns5:pria35s10i>
    <ns5:pria35u3i xml:lang="en">Pedrosa-Harand Andrea</ns5:pria35u3i>
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