<p>This entry represents the IIIC subfamily of the Haloacid Dehalogenase (HAD) superfamily of aspartate nucleophile hydrolases. Subfamily III, which includes subfamily IIIA (<db_xref db="INTERPRO" dbkey="IPR006549"/>) and subfamily IIIB (<db_xref db="INTERPRO" dbkey="IPR005519"/>) contains sequences which do not contain either of the insert domains between the 1st and 2nd conserved catalytic motifs, subfamily I (<db_xref db="INTERPRO" dbkey="IPR006388"/>, <db_xref db="INTERPRO" dbkey="IPR006402"/>, <db_xref db="INTERPRO" dbkey="IPR006439"/>, <db_xref db="INTERPRO" dbkey="IPR006383"/>, <db_xref db="INTERPRO" dbkey="IPR006545"/>, <db_xref db="INTERPRO" dbkey="IPR006434"/>, and <db_xref db="INTERPRO" dbkey="IPR006435"/>), or between the 2nd and 3rd, subfamily II (<db_xref db="INTERPRO" dbkey="IPR006357"/>, and <db_xref db="INTERPRO" dbkey="IPR006379"/>). Subfamily IIIC contains five relatively distantly related clades: a family of viral proteins (<db_xref db="INTERPRO" dbkey="IPR007827"/>), a family of eukaryotic proteins called MDP-1 and a family of archaeal proteins most closely related to MDP-1 (<db_xref db="INTERPRO" dbkey="IPR010036"/>), a family of bacteria including the Streptomyces FkbH protein (<db_xref db="INTERPRO" dbkey="IPR010037"/>), and a small clade including the <taxon tax_id="747">Pasteurella multocida</taxon> BcbF and EcbF proteins. The overall lack of species overlap among these clades may indicate a conserved function, but the degree of divergence between the clades and the differences in architecture outside of the domain in some clades warns against such a conclusion.No member of this subfamily is characterised with respect to function, however the MDP-1 protein [<cite idref="PUB00009589"/>] is a characterised phosphatase. All of the characterised enzymes within subfamily III are phosphatases, and all of the active site residues characteristic of HAD-superfamily phosphatases [<cite idref="PUB00003337"/>] are present in subfamily IIIC.</p> HAD-superfamily phosphatase, subfamily IIIC