<p>This entry represents the enzyme 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, which acts on its two substrates at the same active site, from the Rhizobiales (alphaproteobacteria).This clade of sequences is sufficiently distinct from the characterised proteins [<cite idref="PUB00013756"/>, <cite idref="PUB00013829"/>] which form <db_xref db="INTERPRO" dbkey="IPR010049"/> as to cast some doubt on the accuracy of annotations based on sequence similarity alone. This enzyme is involved in the recycling of the components of S-adenosylmethionine after it has donated one of its two non-ribose sulphur ligands to an acceptor. In the case of 5'-methylthioadenosine this represents the first step of the methionine salvage pathway in bacteria [<cite idref="PUB00013756"/>, <cite idref="PUB00013829"/>]. This enzyme is widely distributed in bacteria.</p> 5-methylthioadenosine/S-adenosylhomocysteine nucleosidase, putative