<p>In <taxon tax_id="562">Escherichia coli</taxon>, UV and many chemicals appear to cause mutagenesis by a process of translesion synthesis that requires DNA polymerase III and the SOS-regulated proteins UmuD, UmuC and RecA. This machinery allows the replication to continue through DNA lesion, and therefore avoid lethal interruption of DNA replication after DNA damage [<cite idref="PUB00010596"/>]. UmuC is a well conserved protein in prokaryotes, with a homologue in yeast species.</p><p>Proteins currently known to belong to this family are listed below:<ul><li>E. coli MucB protein. Plasmid-born analogue of the UmuC protein.</li><li> <taxon tax_id="4932">Saccharomyces cerevisiae</taxon> (Baker's yeast) Rev1 protein. Homologue of UmuC also required for normal induction of mutations by physical and chemical agents. </li><li> <taxon tax_id="602">Salmonella typhimurium</taxon> ImpB protein. Plasmid-born analogue of the UmuC protein.</li><li>Bacterial UmuC protein.</li><li>E. coli DNA-damage-inducible protein P (DinP).</li><li>S. typhimurium SamB homologue of UmuC plasmid associated.</li></ul></p> DNA-repair protein, UmuC-like