BTB/POZ <p>The BTB (for BR-C, ttk and bab) [<cite idref="PUB00004829"/>] or POZ (for Pox virus and Zinc finger)[<cite idref="PUB00001918"/>] domain is present near the N terminus of a fraction of zinc finger(<db_xref db="INTERPRO" dbkey="IPR007087"/>) proteins and in proteins that contain the <db_xref db="INTERPRO" dbkey="IPR006652"/> motif such as Kelch and a family of pox virus proteins.The BTB/POZ domain mediates homomeric dimerisation and in some instancesheteromeric dimerisation [<cite idref="PUB00001918"/>].The structure of the dimerised PLZF BTB/POZ domain has been solved andconsists of a tightly intertwined homodimer. The central scaffolding ofthe protein is made up of a cluster of alpha-helices flanked by shortbeta-sheets at both the top and bottom of the molecule [<cite idref="PUB00004917"/>].POZ domains from several zinc finger proteins have been shown to mediatetranscriptional repression and to interact with components of histonedeacetylase co-repressor complexes including N-CoR and SMRT [<cite idref="PUB00000971"/>, <cite idref="PUB00004499"/>, <cite idref="PUB00003026"/>].The POZ or BTB domain is also known as BR-C/Ttk or ZiN.</p>