HAD superfamily hydrolase-like, type 3 <p>The Haloacid Dehydrogenase (HAD) superfamily includes phosphatases, phosphonatases, P-type ATPases, beta-phosphoglucomutases, phosphomannomutases, and dehalogenases, which are involved in a variety of cellular processes ranging from amino acid biosynthesis to detoxification [<cite idref="PUB00003337"/>]. This HAD domain is found in several distinct enzymes including:<ul><li>Phospholipid-transporting ATPase 1 (<db_xref db="EC" dbkey="3.6.3.1"/>), a putative lipid-flipping enzyme involved in cold tolerance in Arabidopsis [<cite idref="PUB00028126"/>]</li><li>3-deoxy-D-manno-octulosonate (KDO) 8-phosphate phosphatase (<db_xref db="EC" dbkey="3.1.3.45"/>), which catalyses the final step in the biosynthesis of KDO - a component of lipopolysaccharide in Gram-negative bacteria [<cite idref="PUB00028127"/>]</li><li>Mannosyl-3-phosphoglycerate phosphatase (<db_xref db="EC" dbkey="3.1.3.70"/>), which hydrolyzes mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate [<cite idref="PUB00017808"/>]</li><li>Phosphoglycolate phopshatase (<db_xref db="EC" dbkey="3.1.3.18"/>), which catalyses the dephosphorylation of 2-phosphoglycolate [<cite idref="PUB00026943"/>]</li></ul> </p>