<p>This is the C-terminal domain of replication factor C, RFC1. RFC complexes hydrolyse ATP and load sliding clamps such as PCNA (proliferating cell nuclear antigen) onto double-stranded DNA. RFC1 is essential for RFC function in vivo [<cite idref="PUB00020937"/>, <cite idref="PUB00020875"/>]. </p> DNA replication factor RFC1, C-terminal