Leukotriene B4 12-hydroxydehydrogenase/15-oxo-prostaglandin 13-reductase <p>Leukotriene B4 12-hydroxydehydrogenase is an NADP-dependent enzyme of arachidonic acid metabolism, responsible for converting leukotriene B4 to the much less active metabolite 12-oxo-leukotriene B4. The BRENDA database lists leukotriene B4 12-hydroxydehydrogenase as one of the synonyms of 2-alkenal reductase (<db_xref db="EC" dbkey="1.3.1.74"/>), while <db_xref db="EC" dbkey="1.3.1.48"/> is 15-oxoprostaglandin 13-reductase.</p>