<p>Coronin is an actin-binding protein that belongs to the WD40-repeat family proteins and contains 5 WD40 repeats. The WD40 motif is found in a multitude of eukaryotic proteins involved in a variety of cellular processes [<cite idref="PUB00014164"/>]. Repeated WD40 motifs act as a site for protein-protein interaction, and proteins containing WD40 repeats are known to serve as platforms for the assembly of protein complexes or mediators of transient interplay among other proteins. The final 40 amino acids are predicted to form a coiled-coil in a coronin homodimer [<cite idref="PUB00035080"/>].</p> <p>Coronin has been found to localise to actin-rich regions of the cell and binds to F-actin with a K_d of 1-5 nM in yeast. It has also been shown to have actin bundling and nucleation activity, and can bind to microtubules in vivo [<cite idref="PUB00035081"/>]. Coronin has also been shown to bind to and inhibit the Arp2/3 complex in yeast [<cite idref="PUB00035082"/>].</p> Coronin