Phospholipase A2 <p>This entry represents eukaryotic and prokaryotic phospholipase A2 enzymes (PLA2; <db_xref db="EC" dbkey="3.1.1.4"/>), small lipolytic enzymes that releases fatty acids from the second carbon group of glycerol. These enzymes enable the of fatty acids and lysophospholipid by hydrolysing the 2-ester bond of 1,2-diacyl-3-sn-phosphoglycerides.</p><p>The phospholipase domain adopts an alpha-helical secondary structure, consisting of five alpha-helices and two helical segments [<cite idref="PUB00028486"/>, <cite idref="PUB00026999"/>]. In eukaryotes, PLAS plays a pivotal role in the biosynthesis of prostaglandin and other mediators of inflammation.</p>