<p>This entry represents subunit A of Shiga-like toxin also known as rRNA N-glycosidase; <db_xref db="EC" dbkey="3.2.2.22"/>), which are responsible for inactivation of the ribosome. Shiga-like toxins are produced by <taxon tax_id="622">Shigella dysenteriae</taxon> and by bacteriophage that infect <taxon tax_id="562">Escherichia coli</taxon> cells [<cite idref="PUB00042798"/>]. These toxins contain a single A subunit that has N-glycosidase activity and multiple copies of the B subunit that binds to the membrane glycolipid, globotriaosylceramide (Gb3). The A subunit is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits. It catalyses the endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.</p> Shiga-like toxin, subunit A