<p>This group represents an actin-related protein 2/3 complex subunit 1. The complex is an assembly of seven proteins that initiate actin polymerisation in eukaryotic cells [<cite idref="PUB00008559"/>]. WASp (Wiskott-Aldrich syndrome protein)/Scar proteins are thought to activate the Arp2/3 complex by bringing Actin-related protein 2 (Arp2) into proximity with Arp3. Arp2 and Arp3 are folded like actin. Subunit ARPC1 p40 is a seven-blade beta propeller with an insertion that may associate with the side of an actin filament [<cite idref="PUB00008559"/>].</p><p>Tiam1 (T-lymphoma invasion and metastasis 1) interacts with the Arp2/3 complex at sites of actin polymerisation [<cite idref="PUB00043405"/>]. The complex is a potent nucleator of actin filaments that controls a variety of endomembrane functions including the endocytic internalisation of plasma membrane, vacuole biogenesis, plasma-membrane protrusion in crawling cells, and membrane trafficking from the Golgi. The Rac-WAVE-Arp2/3 pathway is an evolutionarily conserved pathway that links actin filament polymerisation to cell morphogenesis [<cite idref="PUB00043406"/>].</p> Actin-related protein 2/3 complex, subunit 1