Mycothiol acetyltransferase <p>Low-molecular weight thiols play an essential role in the metabolism of organsism as coenzymes and cofactors that facilitate important biochemical processes in conjunction with proteins. The predominant low-molecular weight thiol in the actinomycetes is mycothiol, which is involved in the maintenance of cellualar redox state, detoxification of electrophiles and resistance to antimicrobials [<cite idref="PUB00043431"/>, <cite idref="PUB00043432"/>]. The pathway of mycothiol biosynthesis is therefore a potential target for the development of new drugs to treat pathogenic actinomycetes such as <taxon tax_id="1773">Mycobacterium tuberculosis</taxon>.</p><p>This entry represents the MshD protein catalysing the final step of mycothiol biosynthesis, the acetylation of the cysteinyl amine in cysteine-glucosamine-inositol (Cys-GlcN-Ins) [<cite idref="PUB00043433"/>]. MshD is a monomeric enzyme consisting of two tandemly-repeated domains which each adopt the GCN5-related N-acetyltransferase (GNAT) fold [<cite idref="PUB00043433"/>].</p>