Purine phosphorylase, family 2, conserved site <p>Phosphorylases that belong to the same family include, purine nucleoside phosphorylase (<db_xref db="EC" dbkey="2.4.2.1"/>) (PNP) from mammals as well as from some bacteria (gene deoD) (catalyzes the cleavage of guanosine or inosine to respective bases and sugar-1-phosphate molecules) [<cite idref="PUB00002584"/>], 5'-methylthioadenosinephosphorylase (<db_xref db="EC" dbkey="2.4.2.28"/>) (MTA phosphorylase) from eukaryotes [<cite idref="PUB00000256"/>] and xanthosine phosphorylase (<db_xref db="EC" dbkey="2.4.2"/>) from <taxon tax_id="562">Escherichia coli</taxon> (gene xapA) (degrades all purine nucleosides except adenosine and deoxyadenosine) [<cite idref="PUB00002280"/>].Most bacterial PNP and archaebacterial MTA phosphorylases belong to a different group of phosphorylases <db_xref db="INTERPRO" dbkey="IPR000845"/>. A number of uncharacterised proteins also belong to this group.</p>