Pyruvate/ketoisovalerate oxidoreductase, catalytic domain This domain is found in prokaryotes. It includes a region of the large protein pyruvate-flavodoxin oxidoreductase and the whole pyruvate ferredoxin oxidoreductase gamma subunit protein. It is not known whether thegamma subunit has a catalytic or regulatory role. Pyruvateoxidoreductase (POR) catalyses the final step in the fermentationof carbohydrates in anaerobic microorganisms [<cite idref="PUB00002295"/>]. This involves theoxidative decarboxylation of pyruvate with the participation ofthiamine followed by the transfer of an acetyl moiety to coenzymeA for the synthesis of acetyl-CoA [<cite idref="PUB00002295"/>]. The family also includespyruvate flavodoxin oxidoreductase as encoded by the nifJ gene incyanobacterium which is required for growth on molecular nitrogenwhen iron is limited [<cite idref="PUB00004826"/>].