This domain is found in prokaryotic methionyl-tRNA synthetases, prokaryotic phenylalanyl tRNA synthetases the yeast GU4 nucleic-binding protein (G4p1 or p42, ARC1) [<cite idref="PUB00001293"/>], human tyrosyl-tRNA synthetase [<cite idref="PUB00002992"/>],and endothelial-monocyte activating polypeptide II. G4p1 binds specifically to tRNA form a complex with methionyl-tRNA synthetases [<cite idref="PUB00001293"/>]. In human tyrosyl-tRNA synthetase this domain may directtRNA to the active site of the enzyme [<cite idref="PUB00001293"/>]. This domain may perform acommon function in tRNA aminoacylation [<cite idref="PUB00002992"/>]. tRNA-binding domain