<p>The proteasome (or macropain) (<db_xref db="EC" dbkey="3.4.25.1"/>) [<cite idref="PUB00000524"/>, <cite idref="PUB00000148"/>, <cite idref="PUB00004123"/>, <cite idref="PUB00001329"/>, <cite idref="PUB00005460"/>] is a eukaryotic andarchaeal multicatalytic proteinase complex that seems to be involved inan ATP/ubiquitin-dependent nonlysosomal proteolytic pathway. In eukaryotes theproteasome is composed of about 28 distinct subunits which form a highlyordered ring-shaped structure (20S ring) of about 700 kDa.Most proteasome subunits can be classified, on the basis on sequencesimilarities into two groups, alpha (A) and beta (B).</p><p>This family contains the alpha subunit sequences which range from 210 to 290 amino acids. These sequences are classified as non-peptidase homologues in MEROPS peptidase family T1 (clan PB(T)). </p> Proteasome, alpha-subunit, conserved site