Prolyl-tRNA editing protein, YbaK/EbsC <p>This entry represents the YbaK family, bacterial proteins whose full length sequence is homologous to an insertion domain in proline--tRNA ligases. They deacylate mischarged tRNAs.</p><p>The family includes <db_xref db="SWISSPROT" dbkey="P36922"/>, a protein which affects the expression of a receptor called binding substance, that mediates mating aggregate formation in <taxon tax_id="1351">Enterococcus faecalis</taxon> [<cite idref="PUB00017205"/>]. It was suggested that this may be a regulatory protein that suppresses the function or expression of ebsA and/or ebsMB. A crystallographic study of another member of this family, <db_xref db="SWISSPROT" dbkey="P45202"/> from <taxon tax_id="727">Haemophilus influenzae</taxon>, (HI1434, YbaK) suggests that these proteins could be involved in nucleotide or oligonucleotide binding [<cite idref="PUB00010589"/>]. They function in trans to edit the amino acids from incorrectly charged Cys-tRNA(Pro) and also act as weak general deacylases.</p>