Translation initiation factor aIF-2, archaea <p>Initiation factor 2 (IF-2) is one of the three factors required for the initiation of protein biosynthesis. IF-2 promotes the GTP-dependent binding of the initiator tRNA to the small subunit of the ribosome. IF-2 is a protein of about 70 to 95 Kd which contains a central GTP-binding domain flanked by a highly variable N-terminal domain and a more conserved C-terminal domain. Some members of this family undergo protein self splicing that involves a post-translational excision of the intein followed by peptide ligation.</p><p>This entry represents the archael translation initiation factor aIF-2 family.</p>