Lethal(2) giant larvae protein The lethal(2)giant larvae tumour-suppressor gene of Drosophila controls cell proliferation and/ordifferentiation in the optic centres of the brain and the imaginal discs. The structure of the l(2)gl genes,determined by sequencing genomic and cDNA clones, indicates the use of alternative splicing, either inthe 5' untranslated or 3' coding exons. The gene thus encodes two putative proteins, p127 and p78,differing at their C-termini. A 3'-truncated l(2)gl transposon that leaves the coding sequence of p78 intact,but deletes 141 residues of p127, was capable of suppressing tumour formation in l(2)gl-deficient animals[<cite idref="PUB00000814"/>]. Mutations in the Drosophila l(2)gl gene cause malignant transformation of the optic centres ofthe larval brain and imaginal discs. The l(2)gl gene from <taxon tax_id="7237">Drosophila pseudoobscura</taxon> (Fruit fly) shows a high degree ofconservation with the corresponding protein-coding domain from <taxon tax_id="7227">Drosophila melanogaster</taxon> (Fruit fly) [<cite idref="PUB00005948"/>]. These proteins seem to all contain the WD repeats from <db_xref db="INTERPRO" dbkey="IPR001680"/>.