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        <ns1:prib124u1i xml:lang="en">Homing endonucleases are encoded by mobile DNA elements that are found inserted within host genes in all domains of life. The crystal structure of the homing nuclease PI-Sce [&lt;cite idref="PUB00010172"/&gt;] revealed two domains: an endonucleolytic centre resembling the C-terminal domain of &lt;taxon tax_id="7227"&gt;Drosophila melanogaster&lt;/taxon&gt; Hedgehog protein, and a second domain containing the protein-splicing active site. This domain corresponds to the C-terminal domain, which has structural similarity to &lt;db_xref db="INTERPRO" dbkey="IPR001767"/&gt;.</ns1:prib124u1i>
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