Cbl is an adaptor protein that binds EGF receptors (or othertyrosine kinases) and SH3 domains, functioning as a negativeregulator of many signaling pathways. The N-terminal domain isevolutionarily conserved, and is known to bind to phosphorylatedtyrosine residues. The so called N-terminal domain is actually 3structural domains, of which this is the C-terminal SH2 domain. CBL proto-oncogene N-terminus, SH2-like domain Cbl_N3