This family consists of several eukaryoticbeta-catenin-interacting (ICAT) proteins. Beta-catenin is amultifunctional protein involved in both cell adhesion andtranscriptional activation. Transcription mediated by thebeta-catenin/Tcf complex is involved in embryologicaldevelopment and is upregulated in various cancers. ICATselectively inhibits beta-catenin/Tcf binding in vivo, withoutdisrupting beta-catenin/cadherin interactions [1]. Beta-catenin-interacting protein ICAT ICAT