herpes simplex virus thymidine kinase promoter (HSV tk promoter), E.coli neo, herpes simplex virus thymidine kinase polyA additional signal, mouse Rag2 genomic DNA, mouse IL2rb genomic DNA
They lack T, B and NK cells. Furthermore, Macrophages and DCs have some functional defects.
Keio University
C（3〜6か月）
C57BL/6-Rag2tm1Fwa-IL2rbtm1Mak
慶應義塾大学
1998 by Koyasu at Keio Univ. School of Med. Original : Rag2tm1Fwa :1992 by F. W. Alt at Columbia Univ., N.Y. USA IL2rbtm1Och:1995 by T. W. Mak at Ontario Cancer Institute, Toronto, Canada
Nothing special. Breed well.
Nothing special. Breed well.
Cell Biology Research
B6;129-Rag2<tm1Fwa> Il2rb<tm1Mak>/Rbrc
C (3-6 months)
The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEVELOPER (Tak W. Mak, Division of Stem Cell and Developmental Biology, Advanced Medical Discovery Institute/Ontario Cancer Institute E-mail: tmak@uhnresearch.ca).
1998 by Koyasu at Keio Univ. School of Med.Original ：Rag2tm1Fwa :1992 by F. W. Alt at Columbia Univ., N.Y. USAIL2rbtm1Mak:1995 by T. W. Mak at Ontario Cancer Institute, Toronto, CanadaB6.129-Rag2tm1Fwa (N10)×B6.129-IL2rbtm1Mak (N8)→F6-7
C57BL/6-Rag2<tm1Fwa>-IL2rb<tm1Och>
C57BL/6-Rag2<tm1Fwa>-IL2rb<tm1Och>
1998 by Koyasu at Keio Univ. School of Med. Original ： Rag2tm1Fwa :1992 by F. W. Alt at Columbia Univ., N.Y. USA IL2rbtm1Mak:1995 by T. W. Mak at Ontario Cancer Institute, Toronto, Canada B6.129-Rag2tm1Fwa (N10)×B6.129-IL2rbtm1Mak (N8)→F6-7
Shigeo KOYASU
条件を付加する。利用者は事前に寄託者の提供承諾書を得る。<br>利用者はnon-profit organizationを対象とし、Dr. Tak W. Makの許可を得ること。<br>開発者連絡先：Tak W. Mak, Division of Stem Cell and Developmental Biology, Advanced Medical Discovery Institute/Ontario Cancer Institute E-mail: tmak@uhnresearch.ca
Necessary documents for ordering:<ol><li>Approval form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_6.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_d.docx">English</A>)</li><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol><A HREF="https://www.ims.riken.jp/labo/43/index.html" target="_blank">Lab HP</A>
小安 重夫
1998 by Koyasu at Keio Univ. School of Med.Original :Rag2tm1Fwa :1992 by F. W. Alt at Columbia Univ., N.Y. USAIL2rbtm1Och:1995 by T. W. Mak at Ontario Cancer Institute, Toronto, Canada
true
C57BL/6-Rag2tm1Fwa-IL2rbtm1Och
C57BL/6-Rag2tm1Fwa-IL2rbtm1Och
RBRC00522
<a href='https://brc.riken.jp/mus/pcr00522'>Genotyping protocol -PCR-</a>
They lack T, B and NK cells. Furthermore, Macrophages and DCs have some functional defects.
They lack T, B and NK cells. Furthermore, Macrophages and DCs have some functional defects.
Immunology and Inflammation Research