Mice were maintained by successive backcrossing heterozygotes to C57BL/6 mice. Mice were maintained by successive backcrossing heterozygotes to C57BL/6 mice. J1 [129S4/SvJae] Jun ARUGA 有賀　純 mouse zinc finger protein of the cerebellum 1(nervous system specific transcription factor) Zic1 genomic DNA, mouse phosphoglycerate kinase promoter, E. coli neo C（3〜6か月） Developed by Aruga J (Aruga J et al. J Neurosci 18, 284-293, 1998).The mice were frozen-stored at 2-cell stage after in vitro fertilization between a heterozygous male and C57BL/6J females. Live mice were recovered and born on April 28, 2003.Deposited to RIKEN BioResource Center, RIKEN Tsukuba Institute in 2002. Developed by Aruga J (Aruga J et al. J Neurosci 18, 284-293, 1998).The mice were frozen-stored at 2-cell stage after in vitro fertilization between a heterozygous male and C57BL/6J females. Live mice were recovered and born on April 28, 2003.Deposited to RIKEN BioResource Center, RIKEN Tsukuba Institute in 2002. Developed by Aruga J (Aruga J et al. J Neurosci 18, 284-293, 1998). The mice were frozen-stored at 2-cell stage after in vitro fertilization between a heterozygous male and C57BL/6J females. Live mice were recovered and born on April 28, 2003. Deposited to RIKEN BioResource Center, RIKEN Tsukuba Institute in 2002. Developed by Aruga J (Aruga J et al. J Neurosci 18, 284-293, 1998). The mice were frozen-stored at 2-cell stage after in vitro fertilization between a heterozygous male and C57BL/6J females. Live mice were recovered and born on April 28, 2003. Deposited to RIKEN BioResource Center, RIKEN Tsukuba Institute in 2002. B6.129S4-Zic1<tm1Jaru>/JaruRbrc C57BL/6-TgH(Zic1) C (3-6 months) 理化学研究所脳科学総合研究センター RIKEN,BSI 条件を付加する。利用者は事前に寄託者の提供承諾書を得る。<br>研究成果の公表にあたって寄託者の指定する文献を引用する。J. Neurosci., 18, 284-293 (1998). <br>研究成果の公表にあたって謝辞の表明を必要とする。 RBRC00702 Zic genes encode zinc finger proteins. These genes are homologs of the Drosophila pair-rule gene odd-paired. This strain was developed to clarify the function of Zic1 gene. Homozygous Zic1 deficient mice show remarkable ataxia during postnatal development, and die within 1 month. Their cerebella are hypoplastic and missing a lobule in the anterior lobe. A bromodeoxyuridine labeling study indicated a reduction both in the proliferating cell fraction in the external germinal layer (EGL), from embryonic day14, and in forward movement of the EGL (Aruga J et al. J Neurosci 18, 284-293, 1998). Zic genes encode zinc finger proteins. These genes are homologs of the Drosophila pair-rule gene odd-paired. This strain was developed to clarify the function of Zic1 gene. Homozygous Zic1 deficient mice show remarkable ataxia during postnatal development, and die within 1 month. Their cerebella are hypoplastic and missing a lobule in the anterior lobe. A bromodeoxyuridine labeling study indicated a reduction both in the proliferating cell fraction in the external germinal layer (EGL), from embryonic day14, and in forward movement of the EGL (Aruga J et al. J Neurosci 18, 284-293, 1998). The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Neurosci., 18, 284-293 (1998). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. true C57BL/6-TgH(Zic1) C57BL/6-TgH(Zic1) Necessary documents for ordering:<ol><li>Approval form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_6.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_d.docx">English</A>)</li><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol><A HREF="https://www.med.nagasaki-u.ac.jp/phrmch1/index.html" target="_blank">Lab HP</A>