Sibling mating (Homozygote x Homozygote)Homozygous mutant mice are viable and fertile. RIKEN BRC RIKEN BRC The Kit<W-sh> mutation arose spontaneously in the (C3H/HeN x 101/H)F1 at the MRC (Lyon et al., 1982). Homozygous mice are white coat with black eyes. Heterozygotes are black with a white sash. This strain is useful for study of melanogenesis and neural crest migration. C（3〜6か月） RBRC00762 C (3-6 months) Sibling mating (Homozygote x Homozygote) Homozygous mutant mice are viable and fertile. Necessary documents for ordering:<ol><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li></ol> C;B6-a/a-Tyrp1<b>-Kit<W-sh>/Rbrc <a href='https://brc.riken.jp/mus/pcr00762'>Genotyping protocol -PCR-</a> <a href="https://mus.brc.riken.jp/ja/wp-content/uploads/pdf/blc/00762_GB.pdf">Genetic Background</a> C57BL/6-Kit<W-sh> mice were deposited by Dr. Yukihiko Kitamuta, Osaka University to the RIKEN BRC. The mice were backcrossed to BALB/c for several generation, then maintained by sister-brother mating as homozygous state. 兄妹交配による維持。繁殖効率：A C;B6-a/a-b/b-WSh/WSh 雌雄とも繁殖可能。黒目で体は白毛。メラノサイトおよび生殖腺におけるc-kitの機能解析。 W Sash Brown C57BL/6-W<Sh>/+を大阪大学北村幸彦先生より導入。W遺伝子のメラノサイトにおける機能解析のためにBALB/c系統に戻し交配し毛色茶の系統を作出した。BALB;B6-W<Sh>/+のF4代目よりホモ個体を分離してホモ系統として育成をしている。 Reproductive Biology Research false 条件を付加しない。 No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)