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    <ns4:application>Cell Biology Research</ns4:application>
    <ns4:addinfo>&lt;A HREF="https://mus.brc.riken.jp/en/mouse_of_month/jun_2006_mm" target="_blank"&gt;Mouse of the Month June 2006&lt;/A&gt;</ns4:addinfo>
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    <ns1:strainDevelopment xml:lang="ja">理化学研究所脳科学総合研究センター・岩里琢治、糸原重美。E14 ES細胞を用いて作出。C57BL/6背景。</ns1:strainDevelopment>
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    <ns1:donorDNA>Simian virus 40 Large T antigen nuclear localization signal (NLS), phage P1 Cre recombinase, SV40 poly A, yeast FRT (flipase recombination target) sites, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse Emx1 (Drosophila homeobox gene empty spiracles (Ems) mouse homolog) genomic DNA</ns1:donorDNA>
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    <dc:description xml:lang="en">Emx1-cre knock-in mice.  neo type (inserted a cre recombinase gene and a frt flanked PGK-neo cassette into Emx1 gene)(RBRC00808), delta neo type (removed the pgk-neo cassette by FLP mediated recombination)(RBRC01345).  The expression of cre recombinase was observed in dorsal telencephalon, neocortex, hippocampus, and olfactory bulb.  In the delta neo type (RBRC01345), no ectopic cre expression was detected.  Homozygous mice are viable and fertile.</dc:description>
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    <ns4:addinfo>Necessary documents for ordering:&lt;ol&gt;&lt;li&gt;Order form (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Category I MTA: MTA for distribution with RIKEN BRC (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Acceptance of responsibility for living modified organism (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;/ol&gt;</ns4:addinfo>
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    <ns6:brs_depositor xml:lang="en">ShigeYoshi ITOHARA</ns6:brs_depositor>
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    <ns6:brs_depositor xml:lang="ja">糸原　重美</ns6:brs_depositor>
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    <ns1:strainDevelopment xml:lang="en">Developed by Takuji Iwasato and Shigeyoshi Itohara, RIKEN Brain Science Institute.  E14 ES cells were used to generate the mutant mice.  The mice were backcrossed to C57BL/6J.</ns1:strainDevelopment>
    <ns4:termsAndConditions xml:lang="en">In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nature, 406, 726-731 (2000).</ns4:termsAndConditions>
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    <ns4:application>FLP/frt system</ns4:application>
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    <skos:altLabel xml:lang="ja">Emx1-Cre</skos:altLabel>
    <skos:altLabel xml:lang="en">Emx1-Cre</skos:altLabel>
    <ns4:addinfo>&lt;a href='https://brc.riken.jp/mus/pcr00808'&gt;Genotyping protocol -PCR-&lt;/a&gt;</ns4:addinfo>
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    <ns4:termsAndConditions xml:lang="ja">条件を付加する。&lt;br&gt;研究成果の公表にあたって寄託者の指定する文献を引用する。Nature, 406, 726-731 (2000).</ns4:termsAndConditions>
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    <ns1:colonyMaintenance xml:lang="en">Homozygote x Homozygote [or Crossing to C57BL/6JJcl]</ns1:colonyMaintenance>
    <ns1:colonyMaintenance xml:lang="ja">Homozygote x Homozygote [or Crossing to C57BL/6JJcl]</ns1:colonyMaintenance>
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    <ns6:brs_depositorOrganization xml:lang="en">RIKEN,BSI</ns6:brs_depositorOrganization>
    <dc:description xml:lang="ja">Emx1-creノックインマウス。Cre遺伝子とPGK-neoカセットがEmx1遺伝子の翻訳開始コドンATGの前に挿入されているマウス (neo型)  (RBRC00808) とPGK-neoカセットを除去したマウス (delta neo型)  (RBRC01345) 。大脳皮質、海馬、嗅球の興奮性神経細胞特異的にCre組換え酵素を発現する。delta neo型マウス (RBRC01345) では、neo型で観察されたectopic expressionが消失しており、内在性遺伝子の発現特性をより反映している。ホモマウスは生存性、繁殖性ともにあり。</dc:description>
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