44A 44A, c-Maf/2 KO 44A, c-Maf/2 KO Univ. Tsukuba C（3〜6か月） 条件を付加する。利用者は事前に寄託者の提供承諾書を得る。<br>共同研究 Necessary documents for ordering:<ol><li>Approval form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_6.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_d.docx">English</A>)</li><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol><A HREF="https://www.md.tsukuba.ac.jp/basic-med/anatomy/embryology/index_e.html" target="_blank">Lab HP</A> E14 [129P2/OlaHsd] 国立大学法人筑波大学 C (3-6 months) Sibling Mating (Heterozygote x Wild-type)Homozygous mutant mice die within 3 days after birth. Developed by Drs. Shimako Kawauchi and Satoru Takahashi at University of Tsukuba in 1998. Both the neomycin and lacZ gene were inserted and replacing most of the coding region of c-Maf gene. へテロマウスで維持。 1998年、筑波大学　基礎医学系　解剖学・発生学研究室で川内紫真子先生が開発。高橋智先生が責任者 B6;129P2-Maf<tm2Mym>. c-Maf is a transcriptional factor that belongs to the large Maf family. This gene is essential for normal lens development. Homozygous mutant mice show defective differentiation of lens fiber cells, and the expression of crystalin genes was severely impaired in the mice. Immunology and Inflammation Research The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR. ホモ欠損マウスは、生後３日以内に死亡 (原因不明) 。CD4 Th2 細胞においてIL-4の産生が欠損している。目の水晶体の線維細胞の形成が不全。 Sensorineural Research B6;129P2-Maf<tm1Mym>/2Rbrc c-Maf/2 KO <a href='https://brc.riken.jp/mus/pcr00843'>Genotyping protocol -PCR-</a> Satoru TAKAHASHI RBRC00843 true mouse c-Maf genomic DNA, E. coli neomycin phosphotransferase, E. coli lacZ, herpes simplex virus thymidine kinase promoter (HSV tk promoter) 高橋　智 Sibling Mating (Heterozygote x Wild-type) Homozygous mutant mice die within 3 days after birth.