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    <ns1:strainDevelopment xml:lang="ja">2003年、本庶佑先生、京都大学E14細胞(129/Sv由来)のinjectionにより作成したキメラマウスをC57BL/6Jに13代以上戻し交配済。</ns1:strainDevelopment>
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    <ns1:expectedDelivery xml:lang="ja">C（3〜6か月）</ns1:expectedDelivery>
    <ns0:brs_depositorOrganization xml:lang="ja">京都大学</ns0:brs_depositorOrganization>
    <ns1:expectedDelivery xml:lang="en">C (3-6 months)</ns1:expectedDelivery>
    <ns5:addinfo>&lt;a href='https://brc.riken.jp/mus/pcr00891'&gt;Genotyping protocol -PCR-&lt;/a&gt;</ns5:addinfo>
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    <ns5:termsAndConditions xml:lang="en">1) The RECIPIENT shall use the BIOLOGICAL RESOURCE only for academic research for the purpose of publishing the research results.&lt;br&gt;2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE,  an acknowledgment to the DEPOSITOR and a citation of the following literature(s) designated by the DEPOSITOR are requested. Immunity 18, 301-312 (2003).&lt;br&gt;3) RECIPIENT shall notify the PROVIDER upon filing a patent application claiming modification of the BIOLOGICAL RESOURCE or method(s) of manufacture or use(s) of the BIOLOGICAL RESOURCE.</ns5:termsAndConditions>
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    <dc:description xml:lang="ja">細胞分化に重要なNotchシグナルを負に制御する分子Mintの古典的欠損マウス。ホモ接合体は胎生致死する。</dc:description>
    <ns1:colonyMaintenance xml:lang="ja">野生型C57BL/6Jとの交配で飼育。繁殖効率に問題なし。</ns1:colonyMaintenance>
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    <ns1:strainDevelopment xml:lang="en">Developed by Dr. Tasuku Honjo, Kyoto University in 2003.  A pgk-neo was transfered into E14 ES cells to replace nucleotide 4891 of the coding region of Mint.  The Mint deficient mice were backcrossed to C57BL/6 for 16 times.</ns1:strainDevelopment>
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    <ns1:colonyMaintenance xml:lang="en">Backcross to C57BL/6 (Heterozygote x C57BL/6CrSlc) The reproductive performance is good.  Homozygous mutant mice are embryonic lethal.</ns1:colonyMaintenance>
    <ns0:brs_depositor xml:lang="en">Tasuku HONJO</ns0:brs_depositor>
    <ns0:brs_depositorOrganization xml:lang="en">Kyoto Univ.</ns0:brs_depositorOrganization>
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    <dc:description xml:lang="en">B6.129P2-Mint-pending&lt;tm1Hon&gt;/HonRbrc.  Mint, Msx2 interacting nuclear target protein which is a suppressor factor of a Notch/RBP-J signaling pathway play a role in fate determination in various lineages.  Homozygous mutant mice are embryonic lethal due to developmental abnormality of heart, spleen and liver.  This strain is useful for elucidating of Notch/RBP-J signaling pathway mechanism in mammals.</dc:description>
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    <ns5:termsAndConditions xml:lang="ja">条件を付加する。&lt;br&gt;1. 公表を前提とした学術研究に限る。&lt;br&gt;2. 研究成果の公表にあたって寄託者への謝辞の表明並びに寄託者の指定する文献を引用する。Immunity 18, 301-312 (2003).&lt;br&gt;3. 本件リソースの改変体又は本件リソースの生産方法若しくは使用方法に係る特許を出願した場合、その旨を速やかに寄託者に通知する。</ns5:termsAndConditions>
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    <ns1:strainDevelopment xml:lang="ja">2003年、本庶佑先生、京都大学 E14細胞(129/Sv由来)のinjectionにより作成したキメラマウスをC57BL/6Jに13代以上戻し交配済。</ns1:strainDevelopment>
    <ns1:colonyMaintenance xml:lang="en">Backcross to C57BL/6 (Heterozygote x C57BL/6CrSlc)The reproductive performance is good.  Homozygous mutant mice are embryonic lethal.</ns1:colonyMaintenance>
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    <ns1:ESCellLine>E14 [129P2/OlaHsd]</ns1:ESCellLine>
    <ns5:addinfo>Necessary documents for ordering:&lt;ol&gt;&lt;li&gt;Order form (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Category I MTA: MTA for distribution with RIKEN BRC (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Acceptance of responsibility for living modified organism (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;/ol&gt;&lt;A HREF="https://www2.mfour.med.kyoto-u.ac.jp/en/index.html" target="_blank"&gt;Honjo Lab HP&lt;/A&gt;</ns5:addinfo>
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    <ns1:donorDNA>mouse MINT genomic DNA, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo</ns1:donorDNA>
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