名古屋大学 Developmental Biology Research 藤澤　肇 C57BL/6-Nrp1<tmHfu> C57BL/6-Nrp1<tmHfu> Developed by Dr. Hajime Fujisawa, Nagoya University in 1997. A neomycin selection cassette was inserted into a fragment of the sequence encoding the a1 domain of the protein. C57BL/6 background. C57BL/6-Nrp1<tmHfu> C (3-6 months) Immunology and Inflammation Research Cardiovascular Research herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, SV40 poly A, mouse C57BL/6 Neuropilin-1 genomic DNA true Necessary documents for ordering:<ol><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol> In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Neuron, 19, 995-1005 (1997). このマウス系統は、1997年に名古屋大学大学院理学研究科の藤澤肇先生と大学共同利用機関法人自然科学研究機構生理学研究所の八木健先生によって開発された。 B6.Cg-Nrp1<tm1Hfu>. Neuropilin-1, Nrp1 is a type I membrane protein and has been shown to function as a receptor for semaphorin III/D.Nrp1 homozygous mutant mice were embryonic lethal, and show severe abnormalities in the trajectory of the cranial and spinal efferent fibers of the parasympathetic nerve system. TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1] Sibling Mating (Heterozygote x Wild, Heterozygote) Embryonic lethality (Homozygous). Homozygote mutant mice die up to E11. <a href='https://brc.riken.jp/mus/pcr01057'>Genotyping protocol -PCR-</a> Sibling Mating (Heterozygote x Wild, Heterozygote) Embryonic lethality (Homozygous). Homozygote mutant mice die up to E11. RBRC01057 Hematological Research Nagoya Univ. 条件を付加する。<br>研究成果の公表にあたって寄託者の指定する文献を引用する。Neuron, 19, 995-1005 (1997). covid19_infection 特になし。 Hajime FUJISAWA Neurobiology Research C（3〜6か月） Developed by Dr. Hajime Fujisawa, Nagoya University in 1997. A neomycin selection cassette was inserted into a fragment of the sequence encoding the a1 domain of the protein.C57BL/6 background. C57BL/6-Nrp1tmHfu 神経線維の投射異常、神経細胞の移動異常、心臓・血管系の形成異常があり、神経形成、血管形成の制御、免疫系の解析にも適す。