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    <ns5:application>Neurobiology Research</ns5:application>
    <dc:description xml:lang="en">B6.Cg-Tg(Camk2a-Fyn)1Kndl/Rbrc.  Transgenic mice overexpressing native Fyn under the control of the calcium/calmodulin-dependent protein kinase II alpha promoter.  The transgenic Fyn is more expressed at high levels in the neurons of the adult forebrain than the neonatal one.  The transgenic mice exhibit no obvious epileptic behavior, but the kindling of these mice is accelerated by once-daily stimulation of the amygdala.  This strain is useful for elucidation of the role of Fyn tyrosine kinase in synaptic plasticity.</dc:description>
    <ns1:strainDevelopment xml:lang="ja">開発年：1994年開発者：児島伸彦先生機関名：コロンビア大学 Kandel研究室B6/CBA/F1 受精卵にmicro-injection, その後FounderをB6Jと交配により継代 (F23)</ns1:strainDevelopment>
    <ns1:donorDNA>mouse Fyn B cDNA, mouse CaMK IIα promoter</ns1:donorDNA>
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    <ns1:strainDevelopment xml:lang="en">Developed by Dr. Nobuhiko Kojima, National Institute for Physiological Sciences, Japan at 1994.  The FynB fragment including the CaMKII alpha promoter was injected into the pronuclei of B6CBF1 fertilized egges.  The transgenic mice were backcross to C57BL/6J mice for 25 generations. Generation:N23+N2</ns1:strainDevelopment>
    <ns0:brs_depositorOrganization xml:lang="ja">理化学研究所</ns0:brs_depositorOrganization>
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    <dcterms:references rdf:resource="http://identifiers.org/pubmed/10489260"/>
    <ns1:colonyMaintenance xml:lang="ja">Tg+♂をB6J♀と交配により繁殖。繁殖効率：A</ns1:colonyMaintenance>
    <ns1:expectedDelivery xml:lang="ja">C（3〜6か月）</ns1:expectedDelivery>
    <ns1:colonyMaintenance xml:lang="en">Backcross to C57BL/6 (Hemizygote x C57BL/6JJcl)Reproductive performance is good.</ns1:colonyMaintenance>
    <ns5:termsAndConditions xml:lang="ja">条件を付加する。&lt;br&gt;研究成果の公表にあたって寄託者の指定する文献を引用する。Learning and Memory, 5, 429-445 (1998).</ns5:termsAndConditions>
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    <ns1:expectedDelivery xml:lang="en">C (3-6 months)</ns1:expectedDelivery>
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    <ns5:addinfo>&lt;a href='https://brc.riken.jp/mus/pcr01102'&gt;Genotyping protocol -PCR-&lt;/a&gt;</ns5:addinfo>
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    <ns0:brs_depositor xml:lang="ja">児島　伸彦</ns0:brs_depositor>
    <ns5:termsAndConditions xml:lang="en">In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Learning and Memory, 5, 429-445 (1998).</ns5:termsAndConditions>
    <dc:description xml:lang="ja">マウス Fyn B cDNAをCaz+/カルモジュリン依存症プロテインキナーゼ(II)α プロモーターによる過剰発現。</dc:description>
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    <rdfs:label xml:lang="en">B6.Cg-Tg(Camk2a-Fyn)1Kndl/Rbrc</rdfs:label>
    <ns5:addinfo>Necessary documents for ordering:&lt;ol&gt;&lt;li&gt;Order form (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Category I MTA: MTA for distribution with RIKEN BRC (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Acceptance of responsibility for living modified organism (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;/ol&gt;</ns5:addinfo>
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    <ns1:colonyMaintenance xml:lang="ja">Tg+♂をB6J♀と交配により繁殖。 繁殖効率：A</ns1:colonyMaintenance>
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    <ns1:colonyMaintenance xml:lang="en">Backcross to C57BL/6 (Hemizygote x C57BL/6JJcl) Reproductive performance is good.</ns1:colonyMaintenance>
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    <ns1:strainDevelopment xml:lang="en">Developed by Dr. Nobuhiko Kojima, National Institute for Physiological Sciences, Japan at 1994.  The FynB fragment including the CaMKII alpha promoter was injected into the pronuclei of B6CBF1 fertilized egges.  The transgenic mice were backcross to C57BL/6J mice for 25 generations.Generation:N23+N2</ns1:strainDevelopment>
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    <ns0:brs_depositor xml:lang="en">Nobuhiko KOJIMA</ns0:brs_depositor>
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    <ns1:strainDevelopment xml:lang="ja">開発年：1994年 開発者：児島伸彦先生 機関名：コロンビア大学 Kandel研究室 B6/CBA/F1 受精卵にmicro-injection, その後FounderをB6Jと交配により継代 (F23)</ns1:strainDevelopment>
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