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    <rdfs:label xml:lang="en">hairy and enhancer of split-related 1</rdfs:label>
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    <ns5:application>Cell Biology Research</ns5:application>
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    </ns6:organism>
    <ns1:genotypingProtocol rdf:resource="http://mus.brc.riken.jp/DataSheet/pcr01151"/>
    <ns1:strainDevelopment xml:lang="ja">開発年：1999年 開発者：Hiroki Kokubo, Randy L Johnson 機関名：University of Texas M.D. Anderson Cancer Center</ns1:strainDevelopment>
    <ns1:colonyMaintenance xml:lang="ja">SPF化の際のB6マウスの亜系統名と購入元：クレア：B6/N ホモの致死性(繁殖性）：hesr1はviable</ns1:colonyMaintenance>
    <ns5:addinfo>Necessary documents for ordering:&lt;ol&gt;&lt;li&gt;Order form (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Category I MTA: MTA for distribution with RIKEN BRC (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;li&gt;Acceptance of responsibility for living modified organism (&lt;A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx"&gt;Japanese&lt;/A&gt; / &lt;A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx"&gt;English&lt;/A&gt;)&lt;/li&gt;&lt;/ol&gt;&lt;A HREF="https://www.nig.ac.jp/nig/research/organization-top/organization/saga" target="_blank"&gt;Saga Lab HP&lt;/A&gt;</ns5:addinfo>
    <rdfs:label>B6;129S7-Hey1&lt;tm1Kkb&gt;/YsaRbrc</rdfs:label>
    <ns5:addinfo>&lt;a href='https://brc.riken.jp/mus/pcr01151'&gt;Genotyping protocol -PCR-&lt;/a&gt;</ns5:addinfo>
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    <ns0:brs_geneticBackground rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/BackgroundStrain_146"/>
    <ns5:termsAndConditions xml:lang="en">In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.</ns5:termsAndConditions>
    <ns0:brs_depositorOrganization xml:lang="ja">国立遺伝学研究所</ns0:brs_depositorOrganization>
    <ns1:colonyMaintenance xml:lang="ja">SPF化の際のB6マウスの亜系統名と購入元：クレア：B6/Nホモの致死性(繁殖性）：hesr1はviable</ns1:colonyMaintenance>
    <ns0:brs_hasGenomicFeature rdf:parseType="Resource">
    </ns0:brs_hasGenomicFeature>
    <ns5:termsAndConditions xml:lang="ja">条件を付加する。&lt;br&gt;研究成果の公表にあたって謝辞の表明を必要とする。</ns5:termsAndConditions>
    <ns0:brs_depositor xml:lang="ja">相賀　裕美子</ns0:brs_depositor>
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    </ns1:references>
    <ns0:brs_hasGenomicFeature rdf:parseType="Resource">
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    <dc:description xml:lang="ja">neoはぬいていない。</dc:description>
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    </ns0:brs_hasGenomicFeature>
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    <ns0:brs_hasGenomicFeature rdf:parseType="Resource">
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    <ns1:expectedDelivery xml:lang="ja">C（3〜6か月）</ns1:expectedDelivery>
    <ns0:brs_hasAllele rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/brc_allele151"/>
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    <dcterms:identifier>RBRC01151</dcterms:identifier>
    <ns0:brs_strainAvailability rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainAvailability_4"/>
    <ns0:brs_hasGenomicFeature rdf:parseType="Resource">
    </ns0:brs_hasGenomicFeature>
    <ns1:strainDevelopment xml:lang="ja">開発年：1999年開発者：Hiroki Kokubo, Randy L Johnson機関名：University of Texas M.D. Anderson Cancer Center</ns1:strainDevelopment>
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    <ns9:RO_0002162 rdf:resource="http://purl.obolibrary.org/obo/NCBITaxon_10090"/>
    <ns1:isRecombinant rdf:datatype="http://www.w3.org/2001/XMLSchema#boolean"
    >true</ns1:isRecombinant>
    <dc:description xml:lang="en">B6;129S7-Hey1&lt;tm1Kkb&gt;.  Hey1 gene is a member of the hairy and enhancer of split related family of bHLH transcription factors, play a important roles in mediating Notch signaling in the developing cardiac and vascular systems.</dc:description>
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    <ns5:application>Cre/loxP system</ns5:application>
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    <ns0:brs_hasGenomicFeature rdf:parseType="Resource">
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    <skos:altLabel xml:lang="ja">hesr1, hairy and enhancer of split-related 1</skos:altLabel>
    <skos:altLabel xml:lang="en">hesr1, hairy and enhancer of split-related 1</skos:altLabel>
    <ns1:colonyMaintenance xml:lang="en">Sibling Mating Homozygous mutant mice are viable and fertile.</ns1:colonyMaintenance>
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    <ns0:brs_strainTypeLink rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/straintype_14"/>
    <ns0:brs_strainAvailability rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/StrainAvailability_6"/>
    <ns1:donorDNA>Encephalomyocarditis virus (EMCV) internal ribosomal entry site (ires), E. coli lacZ, phage P1 loxP sites, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neo, mouse hairy and enhancer of split-related 1 genomic DNA</ns1:donorDNA>
    <ns1:ESCellLine>AB1 [129S7/SvEvBrd-Hprt&lt;+&gt;]</ns1:ESCellLine>
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    <rdfs:seeAlso rdf:resource="http://www2.brc.riken.jp/lab/animal/detail.php?brc_no=RBRC01151"/>
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    <dcterms:references rdf:resource="http://identifiers.org/pubmed/15680351"/>
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    <ns0:brs_depositor xml:lang="en">Yumiko SAGA</ns0:brs_depositor>
    <ns0:brs_hasGenomicFeature rdf:parseType="Resource">
    </ns0:brs_hasGenomicFeature>
    <ns1:strainDevelopment xml:lang="en">Developed by Drs. H. Kokubo and R.L. Johnson at University of Texas M.D. Anderson Cancer Center in 1999.  A loxP-flanked neo cassette was transferred into AB1 ES cells to replace the bHLH region, from exon 1 to exon 4.  C57BL/6 and 129 mixed background.</ns1:strainDevelopment>
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    <ns1:expectedDelivery xml:lang="en">C (3-6 months)</ns1:expectedDelivery>
    <ns7:SIO_001279 rdf:parseType="Resource">
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    <ns7:SIO_001279 rdf:parseType="Resource">
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    <ns11:citesAsAuthority rdf:resource="http://rdf.ncbi.nlm.nih.gov/pubmed/15680351"/>
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    </ns0:brs_hasGenomicFeature>
    <ns1:colonyMaintenance xml:lang="en">Sibling MatingHomozygous mutant mice are viable and fertile.</ns1:colonyMaintenance>
    <ns0:brs_depositorOrganization xml:lang="en">Natl. Inst. Genet.</ns0:brs_depositorOrganization>
    <ns0:brs_hasGenomicFeature rdf:parseType="Resource">
    </ns0:brs_hasGenomicFeature>
  </rdfs:Class>
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    <ns0:brs_indicatesStrain rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC01151"/>
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  <rdf:Description rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/Phenotype_1017731">
    <ns0:brs_indicatesStrain rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC01151"/>
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  <rdf:Description rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/HealthCertificate_26081">
    <ns0:brs_indicatesStrain rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC01151"/>
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  <rdf:Description rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/HealthCertificate_120758">
    <ns0:brs_indicatesStrain rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC01151"/>
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  <rdf:Description rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/HealthCertificate_120757">
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  <rdf:Description rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/RecoveryTestResult_326">
    <ns0:brs_indicatesStrain rdf:resource="http://metadb.riken.jp/db/rikenbrc_mouse/RBRC01151"/>
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  <rdf:Description rdf:about="http://metadb.riken.jp/db/rikenbrc_mouse/HealthCertificate_26506">
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