phage P1 loxP, mouse FoxH1 genomic DNA Backcross to C57BL/6 (Heterozygote x C57BL/6Cr)Homozygous mutant mice are perinatal lethal. B6;129-FoxH1+/-, FAST+/-, B6;129-FoxH1tm1Hh(B6;129-FoxH1+/-,FAST+/- ) knockout mice B6;129-FoxH1+/-, FAST+/-, B6;129-FoxH1tm1Hh(B6;129-FoxH1+/-,FAST+/- ) knockout mice In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Genes Dev., 15, 1242-1256 (2001). 濱田　博司 Developed by Drs. Masamichi Yamamoto and Hiroshi Hamada at Osaka University in 2001. Foxh1<tm1.1Hmd> mutant mice were generated from Foxh1<tm1Hmd> mutant mice by crossing with cre-expressing line, Tg(ACTB-cre)Miya mice strain. 繁殖効率：A（良好） 形態の異常・奇形がある ホモで不妊／死亡 <a href='https://brc.riken.jp/mus/pcr01229'>Genotyping protocol -PCR-</a> 条件を付加する。<br>研究成果の公表にあたって譲渡者の指定する文献を引用する。Genes Dev., 15, 1242-1256 (2001). B6;129-Foxh1<tm1.1Hmd>/HmdRbrc B6;129-Foxh1<tm1.1Hmd>/HmdRbrc true Developmental Biology Research Osaka Univ. B6;129-Foxh1<tm1.1Hmd>. The transcription factor Foxh1 (horkhead box H1) mediates signaling by transforming growth factor-β, Activin, and Nodal. Foxh1 null deficient mice are perinatal lethal. The embryos of Foxh1 deficient mice exhibit various patterning defects by the loss of Nodal signaling. This mice are useful for the study of Foxh1 gene in vivo. RBRC01229 Hiroshi HAMADA Necessary documents for ordering:<ol><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol> Backcross to C57BL/6 (Heterozygote x C57BL/6Cr) Homozygous mutant mice are perinatal lethal. C (3-6 months) C（3〜6か月） FoxH1 の機能解析のための開発。 繁殖効率：A（良好）形態の異常・奇形があるホモで不妊／死亡 国立大学法人大阪大学 2000年、山本正道先生・坂井靖夫先生・濱田博司先生、大阪大学大学院生命機能研究科が開発ES細胞（R1）より樹立。C57BL/6Jと交配。現在B6;129でB6 側に2世代目同士の交配。 2000年、山本正道先生・坂井靖夫先生・濱田博司先生、大阪大学大学院生命機能研究科が開発 ES細胞（R1）より樹立。C57BL/6Jと交配。現在B6;129でB6 側に2世代目同士の交配。