Saposin D mutant mouse
Tokushima Univ.
B6;129-Psap<tm1Juma>/Rbrc
Junko MATSUDA
特性: Renal tubular degeneration (~2months), cerebellar Purkinje cell degeneration (~4months) with accumulation of hydroxy fatty acid-containing ceramide. Average life span: 10-15months.用途: Neurobiology Research, Sphingolipidosis, Glycosphingolipid Biology, Neurodegeneration
開発年:2004年、 開発者:Junko Matsuda & Kunihiko Suzuki. 機関名:徳島大学&ノースカロライナ大学
RBRC01293
繁殖方法: ヘテロ接合体同士の交配。ホモ接合体同士の交配も可能。
In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Hum. Mol. Genet., 13, 2709-2723 (2004).
Necessary documents for ordering:<ol><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol>
条件を付加する。<br>研究成果の公表にあたって寄託者の指定する文献を引用する。Hum. Mol. Genet., 13, 2709-2723 (2004).
C(3〜6か月)
国立大学法人徳島大学
松田 純子
true
特性: Renal tubular degeneration (~2months), cerebellar Purkinje cell degeneration (~4months) with accumulation of hydroxy fatty acid-containing ceramide. Average life span: 10-15months.,用途: Neurobiology Research, Sphingolipidosis, Glycosphingolipid Biology, Neurodegeneration
<a href='https://brc.riken.jp/mus/pcr01293'>Genotyping protocol -PCR-</a>
Homozygous mutant mice exhibit renal tubular degeneration around 2 months, and a cerebellar Purkinje cell degeneration around 4 months with accumulation of hydroxy fatty acid-containing ceramide. Average life sopan is 10-15 months.
Phage P1 loxP site, mouse prosaposin genomic DNA
Backcross to C57BL/6 (Heterozygote x C57BL/6JJcl)
開発年:2004年、開発者:Junko Matsuda & Kunihiko Suzuki. 機関名:徳島大学&ノースカロライナ大学
Saposin D mutant mouse
Saposin D mutant mouse
Developed by Dr. Junko Matsuda, the University of Tokushima Graduate School and Dr. Kunihiko Suzuki, University of North Carolina at 2004.
C (3-6 months)
Cre/loxP system
Neurobiology Research