C57BL/6-Tg(grm6-lacZ)35Kyo- grm6tm1Kyo true Neurobiology Research Tg: Carrier x Carrier; KO: Homozygote x Homozygote Tg: Carrier x Carrier; KO: Homozygote x Homozygote Grm6-lacZトランスジェニック、Grm6遺伝子ノックアウトのダブルミュータントマウス。 Kyoto Univ. mGluR6-/-/lacZ+ mGluR6-/-/lacZ+ Necessary documents for ordering:<ol><li>Approval form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_6.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_d.docx">English</A>)</li><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol> 国立大学法人京都大学 Developed by Shigetada Nakanishi, Kyoto University Faculty of Medicine. Tg: the transgene was injected into the pronuclei of B6D2F1 fertilized eggs. KO: CCE/EK.CCE ES cells derived from 129S/SvEv-Gpi1<c> were used to generate the mutant mice. C57BL/6 semicongenic. C (3-6 months) <a href='https://brc.riken.jp/mus/pcr01353'>Genotyping protocol -PCR-</a> The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Neurosci., 19, 2568-2579 (1999). J. Neurosci., 17, 3014-3023 (1997). Cell, 80, 757-765 (1995).The RECIPIENT is required to obtain a prior written consent from the DEPOSITOR on use of the BIOLOGICAL RESOURCE. C57BL/6-Tg(Grm6-lacZ)35Kyo- Grm6<tm1Kyo> 条件を付加する。利用者は事前に寄託者の提供承諾書を得る。<br>研究成果の公表にあたって寄託者の指定する文献を引用する。J. Neurosci., 19, 2568-2579 (1999). J. Neurosci., 17, 3014-3023 (1997). Cell, 80, 757-765 (1995).<br>必ず提供承諾書を必要とする。 RBRC01353 mouse mGluR6 promoter, E. coli lacZ, SV40 poly A, E. coli neo, herpes simplex virus thymidine kinase promoter (HSV tk promoter), mouse grm6 genomic DNA Shigetada NAKANISHI 中西　重忠 General Purpose Double mutant mice with transgene and knockout allele. Grm6 (glutamate receptor, metabotropic 6) gene is suggested to be responsible for ON responses in both the rod and cone systems. The transgene is mGluR6 gene fused to the beta-galactosidase reporter gene. This strain is useful for investigating the promoter function of the cell-specific and developmentally regulated expression of mGluR6. C（3〜6か月） 京都大学医学部・中西重忠先生。Tg：B6D2F1受精卵へトランスジーンのインジェクションにより作出。KO：CCE/EK.CCE ES細胞（129S/SvEv-Gpi1<c>由来）を用いて作出。C57BL/6セミコンジェニック。