E14.1 [129P2/OlaHsd] RBRC01420 Necessary documents for ordering:<ol><li>Approval form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_6.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_d.docx">English</A>)</li><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol> true IRF-7-KO, IRF7, IRF-7 knockout mice, C57BL/6J IRF-7-KO, IRF7, IRF-7 knockout mice, C57BL/6J mouse phosphoglycerate kinase promoter (PGK promoter), E. coli beta-geo gene (E. coli neo, E. coli lacZ), mouse IRF-7 genomic DNA IRF7 knockout mice. Exon 2 and 3 of Irf7 gene were replaced with a PGK-beta-geo cassette. Homozygous mutant mice are vulnerable to viral infection with a decreased serum interferon level. IRF-7遺伝子のノックアウトマウス。エクソン2と3をPGK-neoカセットで置換。 <A HREF="https://mus.brc.riken.jp/en/mouse_of_month/may_2005_mm" target="_blank">Mouse of the Month May 2005</A><br><a href="https://mus.brc.riken.jp/ja/wp-content/uploads/pdf/blc/01420_GB.pdf">Genetic Background</a> Fluorescent Proteins/lacZ System Tadatsugu TANIGUCHI 谷口　維紹 Homozygote x Homozygote Homozygote x Homozygote B6;129P2-Irf7<tm1Ttg>/TtgRbrc B6;129P2-Irf7<tm1Ttg>/TtgRbrc 条件を付加する。利用者は事前に寄託者の提供承諾書を得る。 東京大学大学院医学系研究科・本田賢也先生、谷口維紹先生（2001）。E14 ES細胞を用いて作出。C57BL/6セミコンジェニック背景。 国立大学法人東京大学 B（1〜3か月） Developed by Kenya Honda and Tadatsugu Taniguchi, Graduate School of Medicine and Faculty of Medicine, University of Tokyo in 2001. The knockout construct was electroporated into E14 ES cells derived from 129P2/OlaHsd. C57BL/6 semicongenic strain. <a href='https://brc.riken.jp/mus/pcr01420'>Genotyping protocol -PCR-</a> Univ. Tokyo B (1-3 months) The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR.