The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Neurosci. Res., 78, 7-15 (2004).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. RBRC01492 Kazuto KOBAYASHI true Necessary documents for ordering:<ol><li>Approval form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_6.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_d.docx">English</A>)</li><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol><A HREF="https://www.fmu.ac.jp/cms/molgenet/index_html" target="_blank">Lab HP (Japanese)</A> Cre/loxP system B6.Cg-Tg(DBH-cre)9-9Koba/KobaRbrc B6.Cg-Tg(DBH-cre)9-9Koba/KobaRbrc These transgenic mice express Cre recombinase gene under the control of the human dopamin beta hydroxylase (DBH) gene promoter. This strain can be used to make an inducible knock-out by crossing with the other genetically-engineered mice that have a loxP site-flanked sequence of interest. The recombination occurs in typical noradrenergic and adrenergic cell groups as well as in transient catecholaminergic cell types. Line 6-8 (RBRC01297), Line 9-9 (RBRC01492). ドーパミンβ-水酸化酵素 (DBH) 遺伝子のプロモーターの下流に、Cre組み換え酵素遺伝子を持つ。特定神経細胞における条件的遺伝子組み換えに利用できる。ライン6-8 (RBRC01297) 、ライン9-9 (RBRC01492) 。 Carrier x Noncarrier [C57BL/6JJcl] Carrier x Noncarrier [C57BL/6JJcl] C (3-6 months) 福島県立医科大学医学部・小林和人先生（1998）。B6D2F2受精卵にインジェクションにより作出。C57BL/6コンジェニック。 Developed by Kazuto Kobayashi, Fukushima Medical University School of Medicine in 1998. The transgene was injected into the pronuclei of B6D2F2 fertilized eggs. The transgenic mice were backcrossed to C57BL/6J. <a href='https://brc.riken.jp/mus/pcr01492'>Genotyping protocol -PCR-</a> DBH-Cre/9-9 DBH-Cre/9-9 小林　和人 Fukushima Medical University 条件を付加する。利用者は事前に寄託者の提供承諾書を得る。<br>研究成果の公表にあたって寄託者の指定する文献を引用する。J. Neurosci. Res., 78, 7-15 (2004).<br>研究成果の公表にあたって謝辞の表明を必要とする。 human dopamine beta-hydroxylase (DBH) promoter, rabbit beta-globin genomic DNA, P1 phage Cre recombinase gene, SV40 early gene poly A C（3〜6か月） ドーパミンβ-水酸化酵素 (DBH) 遺伝子のプロモーターの下流に、Cre組み換え酵素遺伝子を持つ。特定神経細胞における条件的遺伝子組み換えに利用できる。ライン6-8 (RBRC01297) 、ライン9-9 (RBRC01492) 。, <A HREF="https://mus.brc.riken.jp/en/mouse_of_month/jun_2006_mm" target="_blank">Mouse of the Month June 2006</A> 福島県立医科大学