RBRC01710 B6.129S-Ahr<tm1Yfk>. The aryl hydrocarbon receptor (AhR) (dioxin receptor) is a transcription factor that mediate to catalyze xenobiotic Phase I metabolism. Homozygous mutant mice shows a slightly slower growth rate compared than wild-types for the first few weeks of life. Necessary documents for ordering:<ol><li>Approval form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_6.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_d.docx">English</A>)</li><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol> The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT agrees to include the DEPOSITOR/DEVELOPER as a co-author in any publications resulted by the use of the BIOLOGICAL RESOURCE during the first 2 years after deposition by the DEPOSITOR to the RIKEN BRC. The RECIPIENT should contact the DEPOSITOR in the case of application for any patents or commercial use with the results from the use of the BIOLOGICAL RESOURCE. 条件を付加する。利用者は事前に寄託者の提供承諾書を得る。<br>研究成果の公表にあたって謝辞の表明を必要とする。<br>寄託後2年間は共著を必要とする共同研究とする。当該リソースを使用した研究成果に基づき特許等の申請を行う場合は寄託者と別途協議を行う。 国立大学法人筑波大学 true <a href='https://brc.riken.jp/mus/pcr01710'>Genotyping protocol -PCR-</a> Developed by Drs. Yoshiaki Fujii-Kuriyama and Junsei Mimura at Tohoku University in 1997. The mutant mice are backcrossed to C57BL/6. Yoshiaki FUJII C（3〜6か月） C57BL6/J (N7) AhR(-/-)雌マウスは生殖能が低い AhR(C57BL6j)-/- mouse AhR(C57BL6j)-/- mouse Univ. Tsukuba B6.129S-Ahr<tm1Yfk> B6.129S-Ahr<tm1Yfk> Simian virus 40 Large T antigen nuclear localization signal (NLS), E. coli lacZ, herpes simplex virus thymidine kinase promoter (HSV tk promoter), E. coli neo, SV40 T antigen intron and polyadenylation signal, mouse Ahr genomic DNA CCE/EK.CCE [129S/SvEv-Gpi1<c>] Backcross to C57BL/6 (Heterozygote x C57BL/6JJcl) 藤井　義明 <a href="https://mus.brc.riken.jp/ja/wp-content/uploads/pdf/blc/01710_GB.pdf">Genetic Background</a> C (3-6 months)