慶應義塾大学 CD45 knockout mouse CD45 knockout mouse C.129S2-Ptprc<tm1Tyb>/Rbrc C.129S2-Ptprc<tm1Tyb>/Rbrc Keio University Victor Tybulewiczが作製したCD45のノックアウトマウス。BALB/c バックでホモで交配可能。 Necessary documents for ordering:<ol><li>Approval form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_6.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_d.docx">English</A>)</li><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol><A HREF="https://www.ims.riken.jp/labo/43/index.html" target="_blank">Lab HP</A> The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Eur. immunol., 29, 2923-2933 (1999).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. Research Purpose only. The RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEVELOPER (Dr. Victor Tybulewicz). Shigeo KOYASU mouse Phosphoglycerate kinase-1 (PGK) promoter, E.coli neo, HSV TK PolyA, mouse CD45 genomic DNA C (3-6 months) true 小安　重夫 <a href='https://brc.riken.jp/mus/pcr01730'>Genotyping protocol -PCR-</a> 条件を付加する。利用者は事前に寄託者の提供承諾書を得る。<br>研究成果の公表にあたって寄託者の指定する文献を引用する。Eur. immunol., 29, 2923-2933 (1999).<br>研究成果の公表にあたって謝辞の表明を必要とする。<br>学術研究目的に限る。事前に開発者（Dr. Victor Tybulewicz) に連絡し、必要な手続きを行い、使用許可を得る。 C（3〜6か月） Immunology and Inflammation Research Developed by Dr. Victor L J Tybulewicz at National Institute for Medical Research in 1999. A neo was transfered into D2 ES cells to reolace the exon 12 of the Ptprc gene. BALB/c background. CD45 is a transmembrane tyrosine phosphatase implicated in the control of T cell receptor signaling. CD45 homozygous mutant mice in the BALB/c background were gorssly normal and fertile. RBRC01730 Backcross to BALB/c (Heterozygote x BALB/cAnN) Backcross to BALB/c (Heterozygote x BALB/cAnN)