C（3〜6か月） Tasuku HONJO Necessary documents for ordering:<ol><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol><A HREF="https://www2.mfour.med.kyoto-u.ac.jp/en/index.html" target="_blank">Honjo Lab HP</A> phage P1 loxP sites, mouse Spen genomic DNA Cre/LoxP 系に基づいて、 Mint 遺伝子の条件付き遺伝子欠損が可能。 true Mint floxed mouse Brother / Sister mating特記すべき項目なし。　繁殖効率は普通。 本庶　佑 国立大学法人京都大学 B6.Cg-Spen<tm2.1>. Mint, Msx2 interacting nuclear target protein which is a suppressor factor of a Notch/RBP-J signaling pathway, plays a role in fate determination. This strain has a loxP-flanked Mint allele. Conditional Mint deficient mice can be generated by crossing with tissue-specific Cre mice. This strain is useful for elucidating the mechanism of Notch/RBP-J signaling pathway in mammals. 2004年、矢部大介先生 （京都大学大学院医学研究科） により作出。 遺伝子改変した TT2 細胞株 (CBA x C57BL/6 F1) から作出。10世代以上にわたり兄妹交配。 C (3-6 months) Cre/loxP system 1) The RECIPIENT shall use the BIOLOGICAL RESOURCE only for academic research for the purpose of publishing the research results.<br>2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR and a citation of the following literature(s) designated by the DEPOSITOR are requested. Yabe et al., Genesis 45(5):300-306 (2007).<br>3) RECIPIENT shall notify the PROVIDER upon filing a patent application claiming modification of the BIOLOGICAL RESOURCE or method(s) of manufacture or use(s) of the BIOLOGICAL RESOURCE. 条件を付加する。<br>1. 公表を前提とした学術研究に限る。<br>2. 研究成果の公表にあたって寄託者への謝辞の表明並びに寄託者の指定する文献を引用する。Yabe et al., Genesis 45(5):300-306 (2007).<br>3. 本件リソースの改変体又は本件リソースの生産方法若しくは使用方法に係る特許を出願した場合、その旨を速やかに寄託者に通知する。 Mint floxed mouse, B6.Cg-Spen<tm2.1>/HonRbrc Mint floxed mouse, B6.Cg-Spen<tm2.1>/HonRbrc RBRC02105 Developed by Drs. Diasuke Yabe and Tasuku Honjo at Kyoto University in 2004. Kyoto Univ. B6.Cg-Spen<tm2>. Mint, Msx2 interacting nuclear target protein which is a suppressor factor of a Notch/RBP-J signaling pathway, plays a role in fate determination. This strain has a loxP-flanked Mint allele. Conditional Mint deficient mice can be generated by crossing with tissue-specific Cre mice. This strain is useful for elucidating the mechanism of Notch/RBP-J signaling pathway in mammals. Sibling Mating (Homozygote x Homozygote) <a href='https://brc.riken.jp/mus/pcr02105'>Genotyping protocol -PCR-</a> 2004年、矢部大介先生 （京都大学大学院医学研究科） により作出。遺伝子改変した TT2 細胞株 (CBA x C57BL/6 F1) から作出。10世代以上にわたり兄妹交配。 Brother / Sister mating 特記すべき項目なし。　繁殖効率は普通。 TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1] B6.Cg-Spen<tm2.1Hon>/HonRbrc