human c-Ret cDNA (MEN2A-type mutant), MoMuLV LTR, rat insulin poly A, SV40 poly(A) signal Cancer Research Sibling Mating (Heterozygote x Wild-type) 1999年、川井久美先生が名古屋大で作製。 C (3-6 months) Developed by Dr. K. Kawai, Nagoya University School of Medicine in 1999. C57BL/6 and BALB/c mixed background. ヘテロとWTの交配。ヘテロ同士は不可。短命のため、オスを長期にわたって繁殖に使うのは困難なことが多い。ホモで不妊／死亡 ヘテロで全例甲状腺に腫瘍を形成します。短命のものも多く、長く生きると乳腺、耳下腺に腫瘍形成をみます。 国立大学法人名古屋大学 In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Cancer Researh, 60, 5254-5260 (2000). Masahide TAKAHASHI C（3〜6か月） RBRC02217 true Nagoya Univ. Necessary documents for ordering:<ol><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol> 高橋　雅英 <a href='https://brc.riken.jp/mus/pcr02217'>Genotyping protocol -PCR-</a> Tg2A-121 Tg2A-121 条件を付加する。<br>研究成果の公表にあたって寄託者の指定する文献を引用する。Cancer Researh, 60, 5254-5260 (2000). This transgenic mouse was generated by introducing RET with a MEN2A (cysteine 634 arginine) mutation fused to Moloney murine leukemia virus long terminal repeat. The heterozygous mice develop thyroid C-cell hyperplasia or medullary carcinoma. STOCK Tg(MoMuLV/RET-MEN2A)121Mat STOCK Tg(MoMuLV/RET-MEN2A)121Mat