Necessary documents for ordering:<ol><li>Order form (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_4.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_b.docx">English</A>)</li><li>Category I MTA: MTA for distribution with RIKEN BRC (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_5.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_c.docx">English</A>)</li><li>Acceptance of responsibility for living modified organism (<A HREF="https://mus.brc.riken.jp/ja/wp-content/uploads/form/form_7.docx">Japanese</A> / <A HREF="https://mus.brc.riken.jp/en/wp-content/uploads/form/form_g.docx">English</A>)</li></ol><A HREF="http://www.okano-lab.com/" target="_blank">Lab HP</A> Msi1 deficient miceC57BL/6J background Msi1 deficient mice frequently died of obstructive hydrocephalus within a couple of month with aberrant cell proliferation around cerebral aqueduct. (Sakakibara S et al. Proc Natl Acad Sci USA. 2002) Both male and female are infertile because of the early death of hydrocephalus.On the other hand, CD-1 (ICR) background Msi1 deficient mice survive to adult without gross anatomical phenotype. Since both male and female are fertile, it is possible to mate between Msi1 null mice. (Unpublished data) RBRC04434 条件を付加する。<br>研究成果の公表にあたって寄託者の指定する文献を引用する。Proc. Natl. Acad. Sci. USA, 99, 15194-15199 (2002).<br>利用希望者は、事前に利用条件等につき寄託者と合意し、提供承諾を得ること。 C（3〜6か月） Hideyuki OKANO In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Proc. Natl. Acad. Sci. USA, 99, 15194-15199 (2002).For use of the BIOLOGICAL RESOURCE, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. Developed by Shinsuke Shibata and Hideyuki Okano, Keio University School of Medicine. mouse Musashi1 genomic DNA, E. coli Tn5neo gene, mouse PGK promoter, SV40 polyA Cell Biology Research <a href='https://brc.riken.jp/mus/pcr04434'>Genotyping protocol -PCR-</a> C (3-6 months) 岡野　栄之 Msi1 deficient mice,C57BL/6J background Msi1 deficient mice frequently died of obstructive hydrocephalus within a couple of month with aberrant cell proliferation around cerebral aqueduct. (Sakakibara S et al. Proc Natl Acad Sci USA. 2002) Both male and female are infertile because of the early death of hydrocephalus.,On the other hand, CD-1 (ICR) background Msi1 deficient mice survive to adult without gross anatomical phenotype. Since both male and female are fertile, it is possible to mate between Msi1 null mice. (Unpublished data) B6.129-Msi1<tm1Okn> B6.129-Msi1<tm1Okn> Msi1 deficient mice C57BL/6J background Msi1 deficient mice frequently died of obstructive hydrocephalus within a couple of month with aberrant cell proliferation around cerebral aqueduct. (Sakakibara S et al. Proc Natl Acad Sci USA. 2002) Both male and female are infertile because of the early death of hydrocephalus. On the other hand, CD-1 (ICR) background Msi1 deficient mice survive to adult without gross anatomical phenotype. Since both male and female are fertile, it is possible to mate between Msi1 null mice. (Unpublished data) true C57BL/6J background Msi1 deficient mice (RBRC04434) frequently died of obstructive hydrocephalus within a couple of month with aberrant cell proliferation around cerebral aqueduct. Both male and female are infertile because of the early death of hydrocephalus. On the other hand, CD-1 (ICR) background Msi1 deficient mice (RBRC04435) survive to adult without gross anatomical phenotype. Since both male and female are fertile, it is possible to mate between Msi1 null mice.